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Nitrile Metabolizing Enzymes in Biocatalysis and Biotransformation

Nitrile Metabolizing Enzymes in Biocatalysis and Biotransformation

Tek Chand Bhalla, Vijay Kumar, Virender Kumar, Neerja Thakur, Savitri

Appl Biochem Biotechnol. 2018 Aug;185(4):925-946.

PMID: 29380295

Abstract:

Nitrile metabolizing enzymes, i.e., aldoxime dehydratase, hydroxynitrile lyase, nitrilase, nitrile hydratase, and amidase, are the key catalysts in carbon nitrogen triple bond anabolism and catabolism. Over the past several years, these enzymes have drawn considerable attention as prominent biocatalysts in academia and industries because of their wide applications. Research on various aspects of these biocatalysts, i.e., sources, screening, function, purification, molecular cloning, structure, and mechanisms, has been conducted, and bioprocesses at various scales have been designed for the synthesis of myriads of useful compounds. This review is focused on the potential of nitrile metabolizing enzymes in the production of commercially important fine chemicals such as nitriles, carboxylic acids, and amides. A number of opportunities and challenges of nitrile metabolizing enzymes in bioprocess development for the production of bulk and fine chemicals are discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9024902	Nitrilase		9024-90-2	Price

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