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NMR Studies on 4-thio-5-furan-modified and 4-thio-5-thiophene-modified Nucleosides

NMR Studies on 4-thio-5-furan-modified and 4-thio-5-thiophene-modified Nucleosides

Xiao-Hui Zhang, Yao-Zhong Xu

Magn Reson Chem. 2016 Nov;54(11):887-892.

PMID: 27529164

Abstract:

Systematic NMR characterization of 4-thio-5-furan-pyrimidine nucleosides or 4-thio-5-thiophene-pyrimidine nucleosides (ribonucleosides and 2'-deoxynucleosides) was performed. All proton and carbon signals of 4-thio-5-thiophene-ribouridine and related analogues were unambiguously assigned. The orientations of the base (4-thiouridine or its deoxy analogue) relative to the ring (furan or thiophene) are explored by a NMR approach and further supported by X-ray crystallographic studies. The procedures presented here would be applicable to other modified nucleosides and nucleotides. Copyright © 2016 John Wiley & Sons, Ltd.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP551907643	Thiophene-4		551907-64-3	Price

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