Home
Resources
Publications
NMR Study on the Hydroxy Protons of the Lewis X and Lewis Y Oligosaccharides

NMR Study on the Hydroxy Protons of the Lewis X and Lewis Y Oligosaccharides

Somer Bekiroglu, Lennart Kenne, Corine Sandström

Carbohydr Res. 2004 Oct 4;339(14):2465-8.

PMID: 15388363

Abstract:

The 1H NMR chemical shifts and NOEs of hydroxy protons in Lewis X trisaccharide, beta-D-Galp-(1-->4)[alpha-L-Fucp-(1-->3)]-beta-D-GlcpNAc, and Lewis Y tetrasaccharide, alpha-L-Fucp-(1-->2)-beta-D-Galp-(1-->4)[alpha-L-Fucp-(1-->3)]-beta-D-GlcpNAc, were obtained for 85% H2O/15% (CD3)2CO solutions. The OH-4 signal of Galp in Lewis X and OH-3, OH-4 signals of Galp, and OH-2 signal of Fucp linked to Galp in Lewis Y had chemical shifts which indicate reduced hydration due to their proximity to the hydrophobic face of the Fucp unit linked to GlcpNAc. The inter-residue NOEs involving the exchangeable NH and OH protons confirmed the stacking interaction between the Fucp linked to the GlcpNAc and the Galp residues in Lewis X and Lewis Y.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42410787	Lewis-Y tetrasaccharide			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: