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NO Synthase and Guanylate Cyclase Inhibitors Block Modulation of the Plasticity of Common Snail Cholinoreceptors by 15-hydroxy-eicosatetraenoic Acid

NO Synthase and Guanylate Cyclase Inhibitors Block Modulation of the Plasticity of Common Snail Cholinoreceptors by 15-hydroxy-eicosatetraenoic Acid

A S Pivovarov, W Egido-Villareal

Neurosci Behav Physiol. Sep-Dec 1996;26(5):428-34.

PMID: 9000214

Abstract:

The probable role of two second messengers, nitrogen oxide (NO) and cyclic guanosine monophosphate (cGMP) in the short- and long-latency effects of the acyclic eicosanoid 15(S)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (15-HETE) on the plasticity of somatic cholinoreceptors of identified RPa3 and LPa3 neurons of Helix lucorum, was investigated using the two-electrode voltage clamp technique on the membrane. It was demonstrated that N omega-methyl-L-arginine (an inhibitor of NO synthase), LY-83,583 [sic], and the dye methylene blue (inhibitors of soluble guanylate cyclase), when applied extracellularly, disrupt the short- and long-latency modulatory influences of 15-HETE on the depression of the inward current induced by acetylcholine during its rhythmic application to the soma. The participation of NO and cGMP in the modulatory effects of 15-HETE on the plasticity of cholinoreceptors is hypothesized.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP54845953	15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid		54845-95-3	Price

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