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Nodakenin, a Coumarin Compound, Ameliorates Scopolamine-Induced Memory Disruption in Mice

Nodakenin, a Coumarin Compound, Ameliorates Scopolamine-Induced Memory Disruption in Mice

Dong Hyun Kim, Do Yoon Kim, Young Choong Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Yeong Shik Kim, Sam Sik Kang, Kwang Ho Ko, Jong Hoon Ryu

Life Sci. 2007 May 1;80(21):1944-50.

PMID: 17382968

Abstract:

Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance test and the Y-maze test (P<0.05), and also reduced escape latency during training in the Morris water maze test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP495318	Nodakenin		495-31-8	Price

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