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Non-motor Symptoms Burden, Mood, and Gait Problems Are the Most Significant Factors Contributing to a Poor Quality of Life in Non-Demented Parkinson's Disease Patients: Results From the COPPADIS Study Cohort

Non-motor Symptoms Burden, Mood, and Gait Problems Are the Most Significant Factors Contributing to a Poor Quality of Life in Non-Demented Parkinson's Disease Patients: Results From the COPPADIS Study Cohort

D Santos García, T de Deus Fonticoba, E Suárez Castro, C Borrué, M Mata, B Solano Vila, A Cots Foraster, M Álvarez Sauco, A B Rodríguez Pérez, L Vela, Y Macías, S Escalante, P Esteve, S Reverté Villarroya, etc.

Parkinsonism Relat Disord. 2019 Sep;66:151-157.

PMID: 31409572

Abstract:

Objective:
To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of non-demented Parkinson's disease (PD) patients and compare to a control group.
Methods:
The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures.
Results:
QoL was worse in PD patients (n = 692; 62.6 ± 8.9 years old, 60.3% males) than controls (n = 206; 61 ± 8.3 years old, 49.5% males): PDQ-39, 17.1 ± 13.5 vs 4.4 ± 6.3 (p < 0.0001); PQ-10, 7.3 ± 1.6 vs 8.1 ± 1.2 (p < 0.0001); EUROHIS-QOL8, 3.8 ± 0.6 vs 4.2 ± 0.5 (p < 0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65; p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (β = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas mood and gait problems contributed the most to global QoL (PQ-10, β = -0.46 and -0.21, respectively; EUROHIS-QOL8, β = -0.44 and -0.23, respectively).
Conclusions:
QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP927691212	PQ-10		927691-21-2	Price

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