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Non-pungent Long Chain Capsaicin-Analogs Arvanil and Olvanil Display Better Anti-Invasive Activity Than Capsaicin in Human Small Cell Lung Cancers

Non-pungent Long Chain Capsaicin-Analogs Arvanil and Olvanil Display Better Anti-Invasive Activity Than Capsaicin in Human Small Cell Lung Cancers

John D Hurley, Austin T Akers, Jamie R Friedman, Nicholas A Nolan, Kathleen C Brown, Piyali Dasgupta

Cell Adh Migr. 2017 Jan 2;11(1):80-97.

PMID: 27196129

Abstract:

The nutritional compound capsaicin inhibits the invasion of many types of human cancers. The clinical development of capsaicin as an anti-cancer drug is limited due to its unfavorable side effects like burning sensation, stomach cramps, gut pain and nausea. This study compared the anti-invasive activity of capsaicin to non-pungent long chain capsaicin analogs, namely arvanil and olvanil, in human small cell lung cancer cells. Boyden chamber invasion assays revealed that arvanil and olvanil displayed improved anti-invasive activity relative to capsaicin in human SCLC cells. The results of the Boyden chamber assay were confirmed by the spherical invasion assay, and similar results were obtained. The anti-invasive activity of arvanil, olvanil and capsaicin were independent of TRPV and CB1 receptors. Furthermore, the anti-invasive activity of arvanil, olvanil and capsaicin was mediated by the AMPK pathway. Depletion of AMPK levels by siRNA methodology abrogated the anti-invasive activity of arvanil, olvanil and capsaicin. The non-pungent capsaicin analogs arvanil and olvanil display improved anti-invasive activity relative to capsaicin in human SCLC cells. These agents may represent the second generation of capsaicin-like compounds which are more potent than the parent molecule and have a better side effect profile.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP128007318	Arvanil		128007-31-8	Price

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