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Non-susceptibility Genes to Bombyx Densovirus Type 1, Nid-1 and nsd-1, Affect Distinct Steps of the Viral Infection Pathway

Non-susceptibility Genes to Bombyx Densovirus Type 1, Nid-1 and nsd-1, Affect Distinct Steps of the Viral Infection Pathway

Kurako Kidokoro, Katsuhiko Ito, Dorington O Ogoyi, Hiroaki Abe, Kazuei Mita, Keiko Kadono-Okuda

J Invertebr Pathol. 2010 Jan;103(1):79-81.

PMID: 19836396

Abstract:

In the silkworm Bombyx mori, densovirus type 1 (BmDNV-1) replicates only in the midgut and causes fatal disease. Resistance to BmDNV-1 is determined by two genes, nsd-1 and Nid-1, respectively. Neither of them has been identified yet. We investigated the viral transcript by RT-PCR in inoculated silkworms carrying different sets of nsd-1 and Nid-1 genotype. BmDNV-1 transcript was not detected in nsd-1-carrying strains irrespective of existence of Nid-1 but clearly detected in strains carrying Nid-1 without nsd-1. The result suggests that nsd-1 blocks early step of infection. On the other hand, Nid-1 does not block cell and nucleus entry and viral transcription in nuclei but blocks later step in the viral infection cycle.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP476316582	NID-1		476316-58-2	Price

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