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Noncytotoxic and Antitumour-Promoting Activities of Garcinia Acid Esters From Garcinia Atroviridis Griff. Ex T. Anders (Guttiferae)

Noncytotoxic and Antitumour-Promoting Activities of Garcinia Acid Esters From Garcinia Atroviridis Griff. Ex T. Anders (Guttiferae)

Mukram M Mackeen, Lim Y Mooi, Mohidin Amran, Nashriyah Mat, Nordin H Lajis, Abdul M Ali

Evid Based Complement Alternat Med. 2012;2012:829814.

PMID: 22685487

Abstract:

The in vitro antitumour-promoting, cytotoxic, and antioxidant activities of two ester derivatives of garcinia acid, that is, 2-(butoxycarbonylmethyl)-3-butoxycarbonyl-2-hydroxy-3-propanolide (1) and 1',1''-dibutyl methyl hydroxycitrate (2), that had been previously isolated from the fruits of Garcinia atroviridis Griff. ex T. Anders (Guttiferae), were examined. Based on the inhibition of Epstein-Barr virus early antigen (EBV-EA) activation, compound 1 (IC(50): 70 μM) showed much higher (8-fold) antitumour-promoting activity than compound 2 (IC(50): 560 μM). In addition, both compounds were nontoxic towards CEM-SS (human T-lymphoblastic leukemia) cells (CD(50): >100 μM), Raji (human B-lymphoblastoid) cells (CD(50): >600 μM), and brine shrimp (LD(50): >300 μM). Although the antitumour-promoting activity of compound 1 is moderate compared with the known antitumour promoter genistein, its non-toxicity suggests the potential of compound 1 and related structures as chemopreventive agents. The weak antioxidant activity displayed by both compounds also suggested that the primary antitumour-promoting mechanism of compound 1 did not involve oxidative-stress quenching.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP27750136	(+)-Garcinia acid		27750-13-6	Price

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