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Noninvasive Glucose Monitoring With a Contact Lens and Smartphone

Noninvasive Glucose Monitoring With a Contact Lens and Smartphone

You-Rong Lin, Chin-Chi Hung, Hsien-Yi Chiu, Bo-Han Chang, Bor-Ran Li, Sheng-Jen Cheng, Jia-Wei Yang, Shien-Fong Lin, Guan-Yu Chen

Sensors (Basel). 2018 Sep 22;18(10):3208.

PMID: 30249021

Abstract:

Diabetes has become a chronic metabolic disorder, and the growing diabetes population makes medical care more important. We investigated using a portable and noninvasive contact lens as an ideal sensor for diabetes patients whose tear fluid contains glucose. The key feature is the reversible covalent interaction between boronic acid and glucose, which can provide a noninvasive glucose sensor for diabetes patients. We present a phenylboronic acid (PBA)-based HEMA contact lens that exhibits a reversible swelling/shrinking effect to change its thickness. The difference in thickness can be detected in a picture taken with a smartphone and analyzed using software. Our novel technique offers the following capabilities: (i) non-enzymatic and continuous glucose detection with the contact lens; (ii) no need for an embedded circuit and power source for the glucose sensor; and (iii) the use of a smartphone to detect the change in thickness of the contact lens with no need for additional photo-sensors. This technique is promising for a noninvasive measurement of the glucose level and simple implementation of glucose sensing with a smartphone.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP870778931	3-(4′-Heptyloxyphenoxymethyl)phenylboronic acid		870778-93-1	Price
LS793974	4-(trans-4-Hydroxycyclohexylcarbamoyl)phenylboronic acid			Price

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