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Nonionic Surfactants and Their Effects on Asymmetric Reduction of 2-octanone With Saccharomyces Cerevisiae

Nonionic Surfactants and Their Effects on Asymmetric Reduction of 2-octanone With Saccharomyces Cerevisiae

Yunquan Zheng, Liangbin Li, Xianai Shi, Zhijian Huang, Feng Li, Jianmin Yang, Yanghao Guo

AMB Express. 2018 Jul 6;8(1):111.

PMID: 29978349

Abstract:

In an aqueous buffer system, serious reverse and side reactions were found in the asymmetric reduction of 2-octanone with Saccharomyces cerevisiae. However, some nonionic surfactants added to the aqueous buffer system improved the bioreduction process by decreasing the reverse and side reaction rates in addition to effectively increasing the average positive reaction rate. Further, a shorter carbon chain length of hydrophilic or hydrophobic moieties in surfactants resulted in a higher yield of (S)-2-octanol. The alkylphenol ethoxylate surfactants had a less influence than polyoxyethylenesorbitan trialiphatic surfactants on the product e.e. It suggested that the product e.e. resulting from the change of carbon chain length of the hydrophobic moieties varied markedly compared with the change of carbon chain length of the hydrophilic moiety. Emulsifier OP-10 and Tween 20 markedly enhanced the yield and product e.e. at the concentration of 0.4 mmol L-1 with a yield of 73.3 and 93.2%, and the product e.e. of 99.2 and 99.3%, respectively, at the reaction time of 96 h.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS2121315	Nonionic Surfactants			Price

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