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Nonoxynol-9 in Lubricated Condoms. Results of a Study in Female Prostitutes

Nonoxynol-9 in Lubricated Condoms. Results of a Study in Female Prostitutes

H Ward, A De La Court, V Kitchen

Sex Transm Dis. Sep-Oct 1996;23(5):413-4.

PMID: 8885074

Abstract:

Background and objectives:
Debate continues on the efficacy and safety of intravaginal nonoxynol-9 for the prevention of horizontal transmission of human immunodeficiency and other sexually transmitted diseases. Little attention has been paid to the effects of nonoxynol-9 contained in the lubricant of many condoms.
Goal:
To assess the tolerability of different levels of nonoxynol-9 in condom lubricants.
Study design:
Pilot, randomized, controlled trial in 70 female prostitutes.
Results:
There was no association between dose of nonoxynol-9 and reported symptoms or signs of genital tract inflammation; an increased dose of nonoxynol-9 was associated with increased numbers of polymorphonuclear leukocytes on a vaginal wall smear.
Conclusions:
There is no recognized simple method of defining inflammation in the female genital tract. Future studies of the effects of low-dose nonoxynol-9 on the female genital tract require highly controlled exposures, plus colposcopy with or without vaginal biopsy to define inflammation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP26027383	Nonoxynol 9		26027-38-3	Price

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