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Norepinephrine-induced Cardiac Hypertrophy and Fibrosis Are Not Due to Mast Cell Degranulation

Norepinephrine-induced Cardiac Hypertrophy and Fibrosis Are Not Due to Mast Cell Degranulation

Wilfried Briest, Beate Rassler, Alexander Deten, Heinz-Gerd Zimmer

Mol Cell Biochem. 2003 Oct;252(1-2):229-37.

PMID: 14577597

Abstract:

The norepinephrine (NE)-induced hypertrophy of the left ventricle (LV) in the rat is preceded by increased interleukin (IL)-6 expression and associated with LV fibrosis. We have examined whether the elevated level of IL-6 may be due to mast cell degranulation. Therefore we tested the effect of cromoglycate sodium salt (cromolyn), an inhibitor of mast cell degranulation with anti-inflammatory and membrane-stabilizing activity, on the increased expression of IL-6 mRNA and of mRNAs of proteins involved in the remodelling of the extracellular matrix (ECM) which is induced by NE (0.1 mg/kg x h). After 4 h, the NE-induced increase in IL-6 mRNA expression was not influenced by cromolyn (20 mg/kg x h). Cromolyn-infusion for 3 days did not affect the extent of LV hypertrophy induced by NE, as measured by the LV weight/body weight (LVW/BW) ratio and by atrial natriuretic peptide (ANP) expression. Cromolyn induced a slight depression of the NE-induced elevation of the matrix metalloproteinase (MMP)-2. However, it did not affect the NE-induced elevated levels of mRNAs of collagen I and III and the tissue inhibitor of matrix metalloproteinase (TIMP)-2. Since cromolyn did not reduce the NE-effects in rat hearts in vivo we conclude that mast cell degranulation seems not to be involved in them.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP15826376-B	Cromolyn sodium salt		15826-37-6	Price

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