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Norepinephrine Responses in Rat Renal and Femoral Veins Are Reinforced by Vasoconstrictor Prostanoids

Norepinephrine Responses in Rat Renal and Femoral Veins Are Reinforced by Vasoconstrictor Prostanoids

Patrícia de Souza Rossignoli, Fernanda Zocatelli Yamamoto, Oduvaldo Câmara Marques Pereira, Agnaldo Bruno Chies

Vascul Pharmacol. 2015 Sep;72:93-100.

PMID: 26141930

Abstract:

Norepinephrine (NE) responses are larger in renal and femoral veins compared to phenylephrine (PE). These differences may be due to the subtypes of adrenoceptor involved in these responses or to the involvement of local modulatory mechanisms. Therefore, the present study investigated in organ bath the adrenoceptor subtypes involved in the NE and PE responses in both renal and femoral veins as well as the influence of local mechanisms related to NO and to prostanoids upon these responses. The obtained data showed that the NE responses in these veins were not significantly modified by the selective inhibition of β1 or β2-adrenoceptors as well as AT1 or AT2 receptors. However, yohimbine reduced the NE Rmax in renal veins and, in parallel, right shifted the NE concentration-response curves in femoral veins. In both veins, prazosin reduced the NE Rmax and the clonidine induced a measurable contraction. The endothelium removal attenuated the NE responses in femoral veins, thereby abolishing the differences of NE and PE responses. Furthermore, the NE responses in renal and femoral veins were attenuated by indomethacin, which suppressed the statistical difference in relation to the PE response. In conclusion, a synergism between α1- and α2-adrenoceptors is essential to assure full NE contractile responses in both renal and femoral veins. Thus, by acting simultaneously in these adrenoceptors, NE induces more pronounced contractile responses, in comparison to PE, not only in renal but also in femoral veins. Moreover, this pronounced NE response in both renal and femoral veins appears to involve endothelium-derived vasoconstrictor prostanoids.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP108341180-B	L-(−)-Norepinephrine (+)-bitartrate salt monohydrate	108341-18-0	Price
AP136676910	PD 123,319 di(trifluoroacetate) salt hydrate	136676-91-0	Price
AP3414639	(±)-Norepinephrine (+)-bitartrate salt	3414-63-9	Price
AP54750106	(−)-Isoproterenol (+)-bitartrate salt	54750-10-6	Price
IAR4244532	PL415 trifluoroacetate salt hydrate		Price

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