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Norethindrone acetate versus extended-cycle oral contraceptive (Seasonique ®) in the treatment of endometriosis symptoms: A prospective open-label comparative study

Norethindrone acetate versus extended-cycle oral contraceptive (Seasonique ®) in the treatment of endometriosis symptoms: A prospective open-label comparative study

C Scala, U Leone Roberti Maggiore, F Barra, P L Venturini, S Ferrero

Eur J Obstet Gynecol Reprod Biol. 2018 Mar;222:89-94.

PMID: 29408753

Abstract:

Introduction:
This patient preference prospective study was designed to compare patients' satisfaction in women with endometriosis treated either by an extended-cycle oral contraception (OC) or by norethindrone acetate (NETA).
Methods:
This patient preference prospective study included women of reproductive age with endometriosis. Patients were submitted to one of the following 12 months' treatments: Group A, continuous oral treatment with NETA (2.5 mg/day) and Group B, a 91-day extended-cycle OC (LNG/EE 150/30 mcg for 84 days and EE 10 mcg for 7 days). Patient satisfaction was the primary endpoint.
Results:
There was no statistically significant difference in the rate of satisfied patients at 12-month follow up between the two study groups, 82.2% and 68.4% in Group A and Group B respectively (p = 0.143). At 6 and 12-months, there was a significant amelioration in the intensity of all pain in both groups. The median number of days of unscheduled bleeding during the first cycle was significantly higher in Group B compared to Group A.
Conclusion:
Both NETA and extended-cycle OC are effective in treating pain symptoms related to endometriosis. Extended-cycle OC may cause more unscheduled bleeding, but the rate of satisfaction for those who completed the treatment was similar in the two groups.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51989-B	Norethindrone acetate		51-98-9	Price

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