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Novel and Efficient Preparation of Precursor [188Re(OH2)3(CO)3]+ for the Labeling of Biomolecules

Novel and Efficient Preparation of Precursor [188Re(OH2)3(CO)3]+ for the Labeling of Biomolecules

Sang Hyun Park, Sepp Seifert, Hans-Jurgen Pietzsch

Bioconjug Chem. Jan-Feb 2006;17(1):223-5.

PMID: 16417272

Abstract:

A novel and efficient method for preparing 188Re(I) tricarbonyl precursor [188Re(OH2)3(CO)3]+ has been developed by reacting [188Re]perrhenate with Schibli's kit in the presence of borohydride exchange resin (BER) as a reducing agent and an anion scavenger. The precursor was produced in more than 97% yield by reacting a solution of tetrahydroborate exchange resin (BER, 3 mg), borane-ammonia (BH3.NH3, 3 mg), and potassium boranocarbonate (K2[H3BCO2], 3 mg) in 0.9% saline with a solution of sodium perrhenate (Na188ReO4) with up to 50 MBq and concentrated phosphoric acid (85%, 7 microL) at 60 degrees C for 15 min. HPLC and TLC revealed 0% unreacted [188Re]perrhenate ion and <3% of colloidal 188ReO2. Since the precursor is produced with high radiochemical purity and labeling efficiency under the milder conditions than those required for the conventional reducing agents, the latter can be replaced.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP10466656	Potassium perrhenate		10466-65-6	Price

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