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Novel Block Glycopolymers Prepared as Delivery Nanocarriers for Controlled Release of Bortezomib

Novel Block Glycopolymers Prepared as Delivery Nanocarriers for Controlled Release of Bortezomib

Xiaoting Zhang, Tianyu Yuan, Hailiang Dong, Jiaming Xu, Danyue Wang, Han Tong, Xiaohuan Ji, Bin Sun, Meifang Zhu, Xiaoze Jiang

Colloid Polym Sci. 2018;296(11):1827-1839.

PMID: 30416246

Abstract:

To explore block glycopolymers as novel polymeric delivery nanocarriers for anticancer drug bortezomib (BTZ), three types of block glycopolymers, poly(ethylene glycol)-block-poly(gluconamido ethyl methacrylate) (PEG113-b-PGAMA20), poly(ethylene glycol)-block-poly(styrene)-block-poly(gluconamido ethyl methacrylate) (PEG113-b-PS50-b-PGAMA20), and poly(ethylene glycol)-block-poly(2-(diethyl amino) ethyl methacrylate)-block-poly(gluconamido ethyl methacrylate) (PEG113-b-PDEA50-b-PGAMA20), were synthesized via atom transfer radical polymerization (ATRP) using a PEG-based ATRP macroinitiator. Three glycopolymers possess the capacity to load BTZ via pH-induced dynamic covalent bonding and/or hydrophobic interaction with their specific self-assembly behaviors, and PEG113-b-PS50-b-PGAMA20 carrier maintains the sustain release behavior of BTZ due to the stable micellar structure; PEG113-b-PDEA50-b-PGAMA20 carrier realizes the abrupt release at pH 5.5 by collapse of micellar structure, while PEG113-b-PGAMA20 carrier exhibits the fastest release at studied solution pHs. This study would provide a light to develop novel block glycopolymer carrier for the delivery of anticancer drug bearing boronic acid groups. Graphical abstractᅟᅟ.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7411295	Poly(styrene)-block-poly(ethylene glycol)			Price

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