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Novel Hamamelitannin Analogues for the Treatment of Biofilm Related MRSA infections-A Scaffold Hopping Approach

Arno Vermote, Gilles Brackman, Martijn D P Risseeuw, Tom Coenye, Serge Van Calenbergh

Eur J Med Chem. 2017 Feb 15;127:757-770.

PMID: 27823882

Abstract:

Antimicrobial research is increasingly being focused on the problem of resistance and biofilm formation. Hamamelitannin (HAM) was recently identified as an antimicrobial potentiator for conventional antibiotics towards Staphylococcus aureus. This paper describes the synthesis and biological evaluation of novel hamamelitannin analogues with alternative central scaffolds. Via a ligand-based approach, several interesting compounds with improved synthetic accessibility were identified as potentiators for vancomycin in the treatment of MRSA infections.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP469329 Hamamelitannin Hamamelitannin 469-32-9 Price
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