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Novel Spectrophotometric Determination of Flumethasone Pivalate and Clioquinol in Their Binary Mixture and Pharmaceutical Formulation

Novel Spectrophotometric Determination of Flumethasone Pivalate and Clioquinol in Their Binary Mixture and Pharmaceutical Formulation

Eglal A Abdel-Aleem, Maha A Hegazy, Nour W Sayed, M Abdelkawy, Rehab M Abdelfatah

Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 5;136 Pt B:707-13.

PMID: 25448970

Abstract:

This work is concerned with development and validation of three simple, specific, accurate and precise spectrophotometric methods for determination of flumethasone pivalate (FP) and clioquinol (CL) in their binary mixture and ear drops. Method A is a ratio subtraction spectrophotometric one (RSM). Method B is a ratio difference spectrophotometric one (RDSM), while method C is a mean center spectrophotometric one (MCR). The calibration curves are linear over the concentration range of 3-45 μg/mL for FP, and 2-25 μg/mL for CL. The specificity of the developed methods was assessed by analyzing different laboratory prepared mixtures of the FP and CL. The three methods were validated as per ICH guidelines; accuracy, precision and repeatability are found to be within the acceptable limits.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2002291	Flumethasone pivalate		2002-29-1	Price

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