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NQDI-1 Protects Against Acinar Cell Necrosis in Three Experimental Mouse Models of Acute Pancreatitis

NQDI-1 Protects Against Acinar Cell Necrosis in Three Experimental Mouse Models of Acute Pancreatitis

Xiaochun Xie, Chenchen Yuan, Ling Yin, Qingtian Zhu, Nan Ma, Weiwei Chen, Yanbing Ding, Weiming Xiao, Weijuan Gong, Guotao Lu, Zhenglei Xu, Weiqin Li

Biochem Biophys Res Commun. 2019 Nov 26;520(1):211-217.

PMID: 31587872

Abstract:

NQDI-1, an inhibitor of ASK1, has been reported to have protective effects in several experimental human disease models. However, the role of NQDI-1 in acute pancreatitis (AP) has not been reported. In this study, we found that NQDI-1 could attenuate histological damage of pancreatic tissue as well as the levels of serum amylase and lipase in a mouse model of AP induced by caerulein. Moreover, the production of reactive oxygen species (ROS) and the expression of necrosis-related proteins (RIP3 and p-MLKL) were also reduced after NQDI-1 administration. Correspondingly, we elucidated the effect of NQDI-1 in vitro and found that NQDI-1 protected against pancreatic acinar cells necrosis via decreasing the ROS production and RIP3 and p-MLKL expression. In addition, we identified the protective effect of NQDI-1 on AP through two other mouse models induced by l-arginine and pancreatic duct ligation. Taken together, these findings showed that NQDI-1 could reduce the acinar cells necrosis and alleviate the severity of AP, which may afford a new therapeutic target on pancreatic necrosis in AP clinically.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP175026967	NQDI-1		175026-96-7	Price

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