Home
Resources
Publications
Oenothein B, a Cyclic Dimeric Ellagitannin Isolated From Epilobium Angustifolium, Enhances IFNγ Production by Lymphocytes

Oenothein B, a Cyclic Dimeric Ellagitannin Isolated From Epilobium Angustifolium, Enhances IFNγ Production by Lymphocytes

Andrew G Ramstead, Igor A Schepetkin, Mark T Quinn, Mark A Jutila

PLoS One. 2012;7(11):e50546.

PMID: 23226309

Abstract:

Oenothein B is a polyphenol isolated from Epilobium angustifolium and other plant sources, which has been reported to exhibit immunomodulatory properties. Oenothein B is known to activate myeloid cells and induce the production of IL-1 and other cytokines. However, its effects on lymphocytes are unknown. In this report, we show that oenothein B stimulated innate lymphocytes, including bovine and human γδ T cells and NK cells, resulting in either increased CD25 and/or CD69 expression. We also demonstrate that oenothein B enhanced the production of interferon-γ (IFNγ) by bovine and human NK cells alone and in combination with interleukin-18 (IL-18), a response not observed with other commonly studied polyphenols. Furthermore, we demonstrate that oenothein B enhanced the production of IFNγ by human T cells. Since IFNγ contributes to antitumor, antibacterial, and antiviral cell responses, these data suggest an additional mechanism that could account, at least in part, for the immune enhancing properties of oenothein B.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP104987362	Oenothein B		104987-36-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: