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Oenothein B Suppresses Lipopolysaccharide (LPS)-induced Inflammation in the Mouse Brain

Oenothein B Suppresses Lipopolysaccharide (LPS)-induced Inflammation in the Mouse Brain

Satoshi Okuyama, Nahomi Makihata, Morio Yoshimura, Yoshiaki Amakura, Takashi Yoshida, Mitsunari Nakajima, Yoshiko Furukawa

Int J Mol Sci. 2013 May 7;14(5):9767-78.

PMID: 23652834

Abstract:

Oenothein B has been recently evaluated for its ability to affect inflammatory responses in peripheral tissues. In this study, we examined its effect on the damage to the central nervous system due to systemic inflammation. For this purpose, ICR mice were injected with an intraperitoneal (i.p.) dose of lipopolysaccharide (LPS; 1 mg/kg mouse). When oenothein B was administered per os (p.o.), it suppressed (1) LPS-induced abnormal behavior in open field; (2) LPS-induced microglial activation in the hippocampus and striatum; and (3) LPS-induced cyclooxygenase (COX)-2 production in the hippocampus and striatum of these mice. These results suggest that oenothein B had the ability to reduce neuroinflammation in the brain during systemic inflammation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP104987362	Oenothein B		104987-36-2	Price

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