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Off-label Uses of Topical Pimecrolimus

Off-label Uses of Topical Pimecrolimus

Matthew Ladda, Vijay Sandhu, Arvin Ighani, Jensen Yeung

J Cutan Med Surg. Jul/Aug 2019;23(4):442-448.

PMID: 31053034

Abstract:

Pimecrolimus is a topical calcineurin inhibitor currently approved for second-line use in the management of mild-to-moderate atopic dermatitis in patients age 2 years and older. Given the safety profile and nonsteroidal mechanism of pimecrolimus, there has been significant interest in its use in the treatment of a variety of dermatological conditions. This article reviews research that has been published on the off-label uses of topical pimecrolimus, with a focus on published RCTs. Convincing evidence exists supporting pimecrolimus' efficacy in oral lichen planus and seborrheic dermatitis. For other conditions studied to date, pimecrolimus may prove to be a useful treatment alternative when conventional agents fail. Adverse events seen with its off-label use were typically application site reactions, the most common being a transient burning sensation. In summary, pimecrolimus appears to be an effective agent in the treatment of multiple dermatological conditions and may be worth considering as a pharmacologic alternative in several conditions when first-line treatment fails, or for areas that are more susceptible to the adverse effects of topical corticosteroids.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP137071320	Pimecrolimus		137071-32-0	Price

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