Home
Resources
Publications
Older Adults With Heart Failure Treated With Carvedilol, Bisoprolol, or Metoprolol Tartrate: Risk of Mortality

Older Adults With Heart Failure Treated With Carvedilol, Bisoprolol, or Metoprolol Tartrate: Risk of Mortality

Sylvie Perreault, Simon de Denus, Michel White, Brian White-Guay, Michel Bouvier, Marc Dorais, Marie-Pierre Dubé, Jean-Lucien Rouleau, Jean-Claude Tardif, Sarah Jenna, Benjamin Haibe-Kains, Richard Leduc, etc.

Pharmacoepidemiol Drug Saf. 2017 Jan;26(1):81-90.

PMID: 27859924

Abstract:

Purpose:
The long-term use of β-blockers has been shown to improve clinical outcomes among patients with heart failure (HF). However, a lack of data persists in assessing whether carvedilol or bisoprolol are superior to metoprolol tartrate in clinical practice. We endeavored to compare the effectiveness of β-blockers among older adults following a primary hospital admission for HF.
Methods:
We conducted a cohort study using Quebec administrative databases to identify patients who were using β-blockers, carvedilol, bisoprolol, or metoprolol tartrate after the diagnosis of HF. We characterized the patients by the type of β-blocker prescribed at discharge of their first HF hospitalization. An adjusted multivariate Cox proportional hazards model was used to compare the primary outcome of all-cause mortality. We also conducted analyses by matching for a propensity score for initiation of β-blocker therapy and assessed the effect on primary outcome.
Results:
Among 3197 patients with HF with a median follow-up of 2.8 years, the crude annual mortality rates (per 100 person-years) were at 16, 14.9, and 17.7 for metoprolol tartrate, carvedilol, and bisoprolol, respectively. Adjusted hazard ratios of carvedilol (hazard ratio 0.92; 0.78-1.09) and bisoprolol (hazard ratio 1.04; 0.93-1.16) were not significantly different from that of metoprolol tartrate in improving survival. After matching for propensity score, carvedilol and bisoprolol showed no additional benefit with respect to all-cause mortality compared with metoprolol tartrate.
Conclusions:
Our evidence suggests no differential effect of β-blockers on all-cause mortality among older adults with HF. Copyright © 2016 John Wiley & Sons, Ltd.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP56392177-B	Metoprolol Tartrate		56392-17-7	Price
IAR4242160	Alvameline tartrate			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: