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Olfactory Sensitivity for Aliphatic Ketones in Squirrel Monkeys and Pigtail Macaques

Olfactory Sensitivity for Aliphatic Ketones in Squirrel Monkeys and Pigtail Macaques

Matthias Laska, Vera Miethe, Cornelia Rieck, Karin Weindl

Exp Brain Res. 2005 Jan;160(3):302-11.

PMID: 15300348

Abstract:

Using a conditioning paradigm, the olfactory sensitivity of three squirrel monkeys and three pigtail macaques for homologous series of aliphatic 2-ketones (2-butanone to 2-nonanone), symmetrical ketones (3-pentanone to 6-undecanone), and C7-ketones (2-heptanone to 4-heptanone) was assessed. In the majority of cases, the animals of both species significantly discriminated concentrations below 1 ppm from the odorless solvent, and with 2-nonanone and 5-nonanone the monkeys even demonstrated thresholds below 1 ppb. The results showed both primate species have a well-developed olfactory sensitivity for aliphatic ketones, and pigtail macaques generally perform better than squirrel monkeys in detecting members of this class of odorants. Further, in both species tested, we found a significant negative correlation between perceptibility in terms of olfactory detection thresholds and carbon-chain length of both the 2-ketones and the symmetrical ketones, but not between detection thresholds and position of the functional group with the C7-ketones. These findings lend further support to the growing body of evidence suggesting that between-species comparisons of the number of functional olfactory receptor genes or of neuroanatomical features are poor predictors of olfactory performance.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP927491	6-Undecanone		927-49-1	Price

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