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Oligonucleotide Stabilized Silver Nanoclusters as Fluorescence Probe for drug-DNA Interaction Investigation

Oligonucleotide Stabilized Silver Nanoclusters as Fluorescence Probe for drug-DNA Interaction Investigation

Jipei Yuan, Weiwei Guo, Erkang Wang

Anal Chim Acta. 2011 Nov 14;706(2):338-42.

PMID: 22023870

Abstract:

In this work, oligonucleotide stabilized silver nanoclusters as novel fluorescent probes were successfully utilized for the drug-DNA interaction study. Silver nanoclusters were proved to be sensitive probes for the drugs investigated (including of two kinds of intercalators, daunorubicin and quinacrine, as well as a non-intercalating binder bisBenzimide H 33258), as the detection limits at 10(-8) mol L(-1) level of studied drugs can be achieved. The interactions of drugs and calf thymus DNA were investigated using non-linear fit analysis, and the binding constants as well as binding site sizes were obtained. As biocompatible materials, silver nanoclusters are promising in the chemical especially biochemical analysis fields.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23491454-A	bisBenzimide H 33258		23491-45-4	Price

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