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On the Mechanism of Formation and the Synthesis of Pantoprazole Sodium Sesquihydrate-Related Compound E: A Phantom Chemical Entity

Ahmad Yari, Amin Zolali, Khashayar Karimian

ACS Omega. 2019 Jan 9;4(1):737-744.

PMID: 31459358

Abstract:

A mechanism for the formation of pantoprazole related compound E (RC E) is proposed involving the formation of a radical cation in the pH range of 5-8. pH dependence of RC E is demonstrated, and the contribution of the difluoromethoxy group in stabilizing the C-6 free radical, a prerequisite to the formation of the dimer byproduct, is discussed. Also, the synthesis of pantoprazole RC E is reported using the benzidine rearrangement.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP127780169 Pantoprazole Related Compound A Pantoprazole Related Compound A 127780-16-9 Price
AP97963627 Pantoprazole Related Compound C Pantoprazole Related Compound C 97963-62-7 Price
CS31042704 Pantoprazole Related Compound E Pantoprazole Related Compound E Price
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