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Oncostatin M and interleukin-31: Cytokines, Receptors, Signal Transduction and Physiology

Oncostatin M and interleukin-31: Cytokines, Receptors, Signal Transduction and Physiology

Heike M Hermanns

Cytokine Growth Factor Rev. 2015 Oct;26(5):545-58.

PMID: 26198770

Abstract:

Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respective receptor complexes they signal mainly via the JAK/STAT pathway. Besides sharing many biochemical properties, both display divergent physiological functions. This review summarizes aspects of cytokine transcription and biosynthesis, cytokine-receptor interactions, cross-species activities, signal transduction and physiology delineated from recent findings in genetic mouse models for both cytokines, OSM and IL-31.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP106956325-A	Oncostatin M from mouse		106956-32-5	Price
IAR42413394	IL-31 from mouse			Price

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