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One-pot Fabricating Fe3O4/graphene Nanocomposite With Excellent Biocompatibility and Non-Toxicity as a Negative MR Contrast Agent

One-pot Fabricating Fe3O4/graphene Nanocomposite With Excellent Biocompatibility and Non-Toxicity as a Negative MR Contrast Agent

Ping Zan, Chunyan Yang, Huan Sun, Lijun Zhao, Zhongwen Lv, Yuquan He

Colloids Surf B Biointerfaces. 2016 Sep 1;145:208-216.

PMID: 27182656

Abstract:

We report a facile approach to synthesize water-dispersible nanocomposite with Fe3O4 nanoparticles (NPs) attached to graphene (G), which combines the growth of Fe3O4NPs and the reduction of graphene oxide (GO) in one single step. The unique hydrophilic surface structure of Fe3O4/G nanocomposite leads to it being colloidally stable, non-cytotoxic, well-dispersible and biocompatible in aqueous solution verified via bio-experiments. In vivo tests also prove that Fe3O4/G nanocomposite, which can be cleared from the body through the metabolic processes, is harmless to the living body. Most importantly, the Fe3O4/G nanocomposite showed T2relaxivity (123.04mM(-1)s(-1)) indicating its potential as a sensitive T2 contrast agent.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS71750	Fe3O4/graphene nanocomposite			Price

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