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One-Pot Generation of Functionalized Benzynes From Readily Available 2-Hydroxyphenylboronic Acids

Takashi Ikawa, JingKai Sun, Akira Takagi, Shuji Akai

J Org Chem. 2020 Mar 6;85(5):3383-3392.

PMID: 32013426

Abstract:

We developed a one-pot method for the generation of benzynes from a range of readily available 2-hydroxyphenylboronic acids. This method features the in situ activation of both boronic acid and hydroxyl groups of the substrate to enhance benzyne generation at 60 °C. Such mild conditions facilitate the generation of functionalized benzynes that immediately react with diverse arynophiles to produce multisubstituted fused benzenes.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
LS793859 2-Hydroxyphenylboronic acid 2-Hydroxyphenylboronic acid Price
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