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Optical Resolution of (RS)-Denopamine to (R)-Denopamine P-D- Glucoside by Glucosyltransferase From Phytolacca Americana Expressed in Recombinant Escherichia Coli

Hiroki Hamada, Shouta Okada, Kei Shimoda, Daisuke Uesugi, Hatsuyuki Hamada

Nat Prod Commun. 2016 Aug;11(8):1121-1122.

PMID: 30725573

Abstract:

The optical resolution of racemic compounds by stereoselective glucosylation was investigated using plant glucosyltransferase from Phytolacca americana expressed in recombinant Escherichia coli. The glucosyltransferase glucosylated chemoselectively the phenolic hydroxyl group of phenol compounds. The (R)-stereoselective glucosylation of (RS)-denopamine by glucosyltransferase occurred to give (R)-denopamine β-D-glucoside.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP71771909 R(−)-Denopamine R(−)-Denopamine 71771-90-9 Price
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