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Oral Administration of Proteus Mirabilis Damages Dopaminergic Neurons and Motor Functions in Mice

Oral Administration of Proteus Mirabilis Damages Dopaminergic Neurons and Motor Functions in Mice

Jin Gyu Choi, Namkwon Kim, In Gyoung Ju, Hyeyoon Eo, Su-Min Lim, Se-Eun Jang, Dong-Hyun Kim, Myung Sook Oh

Sci Rep. 2018 Jan 19;8(1):1275.

PMID: 29352191

Abstract:

Recently, studies on the relationship between gut dysbiosis and Parkinson's disease (PD) have increased, but whether a specific gut bacterium may cause PD remains unexplored. Here, we report, for the first time, that a specific gut bacterium directly induces PD symptoms and dopaminergic neuronal damage in the mouse brain. We found that the number of Enterobacteriaceae, particularly Proteus mirabilis, markedly and commonly increased in PD mouse models. Administration of P. mirabilis isolated from PD mice significantly induced motor deficits, selectively caused dopaminergic neuronal damage and inflammation in substantia nigra and striatum, and stimulated α-synuclein aggregation in the brain as well as in the colon. We found that lipopolysaccharides, a virulence factor of P. mirabilis, may be associated in these pathological changes via gut leakage and inflammatory actions. Our results suggest a role of P. mirabilis on PD pathogenesis in the brain.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7413156	Lipopolysaccharides from Proteus mirabilis			Price

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