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Oral Bioaccessibility and Health Risk Assessment of vanadium(IV) and vanadium(V) in a Vanadium Titanomagnetite Mining Region by a Whole Digestive System In-Vitro Method (WDSM)

Oral Bioaccessibility and Health Risk Assessment of vanadium(IV) and vanadium(V) in a Vanadium Titanomagnetite Mining Region by a Whole Digestive System In-Vitro Method (WDSM)

Ya-Qi Yu, Jin-Yan Yang

Chemosphere. 2019 Jan;215:294-304.

PMID: 30321809

Abstract:

Oral bioaccessibility of vanadium(IV) and vanadium(V) in soil, dust and concentrate fines from a vanadium titanomagnetite mining region was assessed by a whole digestive system in-vitro scheme. The scheme including the addition of sweat and the large intestinal digestion was used to estimate the oral bioaccessibility of vanadium(IV) and vanadium(V) in the whole digestive system for the first time. Higher oral bioaccessibility of vanadium(IV) and vanadium(V) was determined in gastric and small intestinal phases demonstrating that their major roles for vanadium digestion and absorption. The decreasing order of the oral bioaccessibility of vanadium(IV) and vanadium(V) in each digestive phase was stomach, small intestine, large intestine and mouth. Higher oral bioaccessibility of vanadium(V) in the whole digestion indicated its higher risk potential for human than vanadium(IV). Lower oral bioaccessibility of vanadium(IV) and vanadium(V) determined in bionic digestion illustrated detoxicity potential of human body for ingested vanadium. Compared with soil and dust, higher digestion rate of vanadium in vanadium titanomagnetite concentrate fines indicated its higher risk for human, especially for mining workers. Based on vanadium oral bioaccessibility, hazard quotients of the vanadium were much less than the critical level suggested for no non-carcinogenic risks to the populations surrounding the sampling sites. Indeed, compared with the estimations based on total vanadium content, the incorporation of oral vanadium bioaccessibility into risk assessments could give more realistic information.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1686222	Vanadium(V) oxytriethoxide		1686-22-2	Price

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