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Osmotic Delivery Systems for the Beta-Adrenoceptor Antagonists Metoprolol and Oxprenolol: Design and Evaluation of Systems for Once-Daily Administration

Osmotic Delivery Systems for the Beta-Adrenoceptor Antagonists Metoprolol and Oxprenolol: Design and Evaluation of Systems for Once-Daily Administration

F Theeuwes, D R Swanson, G Guittard, A Ayer, S Khanna

Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):69S-76S.

PMID: 4005132

Abstract:

The essential features and mode of action of oral osmotic drug delivery systems (Oros) for metoprolol fumarate and oxprenolol succinate are described. Critical aspects in the development of systems for once-daily administration of both drugs are discussed, and methods for evaluating in vitro release characteristics are presented. In vitro testing confirmed that drug delivery corresponded closely to the theoretical release behaviour predicted from the physicochemical and membrane permeability characteristics for both oxprenolol and metoprolol systems. In vitro release rates were also shown to be unaffected by pH, in vitro test procedures, dissolution media and long-term storage at different temperatures.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP119637660	Metoprolol fumarate		119637-66-0	Price

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