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Osteopontin as a Link Between Inflammation and Cancer: The Thorax in the Spotlight

Anne-Sophie Lamort, Ioanna Giopanou, Ioannis Psallidas, Georgios T Stathopoulos

Cells. 2019 Aug 2;8(8):815.

PMID: 31382483

Abstract:

The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42413804 Osteopontin human Osteopontin human Price
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