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Outcomes of Extremely Premature Infants With Twin-Twin Transfusion Syndrome Treated by Laser Therapy

Outcomes of Extremely Premature Infants With Twin-Twin Transfusion Syndrome Treated by Laser Therapy

Julie Sommer, Anne-Monique Nuyt, François Audibert, Véronique Dorval, Sandrine Wavrant, Gabriel Altit, Anie Lapointe

J Perinatol. 2018 Nov;38(11):1548-1555.

PMID: 30177860

Abstract:

Objective:
To compare short-term and long-term outcomes of preterm infants born at <29 weeks of gestational age (GA) with twin-twin transfusion syndrome (TTTS) treated with laser therapy to preterm twin infants without TTTS.
Design:
Retrospective case-control study comparing 33 preterm TTTS twins to 101 preterm diamniotic-dichorionic (di-di) twins born at our institution between 2006 and 2015.
Results:
GA at birth were 26.4 ± 1.4 weeks (TTTS) and 26.9 ± 1.6 weeks (di-di) (p = 0.07). TTTS premature newborns were less exposed to antenatal steroids (p = 0.01), more frequently born by C-section (p = 0.005), received more surfactant therapy (p = 0.004, and were smaller for GA (p < 0.001). When adjusted for antenatal steroids and birth weight, TTTS status was not associated with increased mortality (HR 1.66, 95% CI 0.77-3.56, p = 0.20). No differences were found on neurodevelopmental outcomes at 18 months of corrected GA.
Conclusion:
Premature TTTS newborns treated with fetal laser therapy had similar survival and neurodevelopmental outcomes compared to preterm di-di twins without TTTS.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1609131783	Di-PDI		1609131-78-3	Price

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