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Oxidative Pathways of Arachidonic Acid as Targets for Regulation of Platelet Activation

Andres Trostchansky, Rodrigo Moore-Carrasco, Eduardo Fuentes

Prostaglandins Other Lipid Mediat. 2019 Dec;145:106382.

PMID: 31634570

Abstract:

Platelet activation plays an important role in acute and chronic cardiovascular disease states. Multiple pathways contribute to platelet activation including those dependent upon arachidonic acid. Arachidonic acid is released from the platelet membrane by phospholipase A2 action and is then metabolized in the cytosol by specific arachidonic acid oxidation enzymes including prostaglandin H synthase, 12-lipoxygenase, and cytochrome P450 to produce pro- and anti-inflammatory eicosanoids. This review aims to analyze the role of arachidonic acid oxidation on platelet activation, the enzymes that use it as a substrate associated as novel therapeutics target for antiplatelet drugs.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP506321 Arachidonic acid Arachidonic acid 506-32-1 Price
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