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Oxidative Stress, Genotoxicity and Cytotoxicity of 1-methyl-3-octylimidazolium Chloride on Paramisgurnus Dabryanus

Oxidative Stress, Genotoxicity and Cytotoxicity of 1-methyl-3-octylimidazolium Chloride on Paramisgurnus Dabryanus

Ping Nan, Shuai-Guo Yan, Ya-Xing Wang, Qi-Yan Du, Zhong-Jie Chang

Environ Toxicol Pharmacol. 2016 Oct;47:1-5.

PMID: 27566493

Abstract:

This study evaluated the toxicity of 1-methyl-3-octylimidazolium chloride ([C8mim]Cl) on Paramisgurnus dabryanus by enzyme analysis, comet assay, and apoptosis analysis. The study showed that [C8mim]Cl had an obvious toxic effect inducing oxidative stress, genotoxicity, and cytotoxicity to fish liver cells. [C8mim]Cl also induced changes in the activities of superoxide dismutase and catalase, and the glutathione content and malondialdehyde level in fish exposed at 20-80mgL-1. With increased exposure concentration and time, the four antioxidant enzyme activities, three different comet parameters and apoptosis rates of tested cells were significantly increased, with significant differences (P<0.05 or P<0.01) observed between control group and each treatment group. This study shows that [C8mim]Cl could be a threat to aquatic organism health when accidentally released into aquatic ecosystems.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP64697401	1-Methyl-3-octylimidazolium chloride		64697-40-1	Price

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