Home
Resources
Publications
p-Coumaric Acid Improves Oxidative and Osmosis Stress Responses in Caenorhabditis Elegans

p-Coumaric Acid Improves Oxidative and Osmosis Stress Responses in Caenorhabditis Elegans

Yiren Yue, Peiyi Shen, Yuejia Xu, Yeonhwa Park

J Sci Food Agric. 2019 Feb;99(3):1190-1197.

PMID: 30047165

Abstract:

Background:
Stress-response pathways in Caenorhabditis elegans (C. elegans) were found to be closely related to human diseases and aging. Research on stress responses in C. elegans can therefore significantly facilitate understanding of related human diseases. p-Coumaric acid is present in peanuts, carrots, and garlic, and exerts many biological effects, however, its responses to various environmental stressors remain unknown. Thus, in the current study, we employed C. elegans as the in vivo animal model to examine the function of p-coumaric acid under various stressed conditions.
Results:
Treatment of C. elegans with p-coumaric acid resulted in a significant reduction in the intercellular reactive oxygen species levels, which suggests the in vivo antioxidant capacity of p-coumaric acid. Moreover, p-coumaric acid significantly increased the worms' survival under oxidative and osmosis stressed conditions but had no effect under normal or heat-stressed conditions. The increased oxidative resistance induced by p-coumaric acid was mediated by skn-1, an ortholog of the Nrf2 (nuclear factor erythroid 2-related factor 2) transcriptional factor. Downregulation of the osmosis regulatory gene, osr-1, might contribute to p-coumaric acids' effect on increased resistance to high osmolarity.
Conclusion:
Taken together, our results suggest that p-coumaric acid, an antioxidant agent, ameliorated oxidative and osmosis stresses in C. elegans. © 2018 Society of Chemical Industry.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP501984-B	p-Coumaric acid		501-98-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: