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p-Terphenyl and Diterpenoid Metabolites From Endophytic Aspergillus Sp. YXf3

p-Terphenyl and Diterpenoid Metabolites From Endophytic Aspergillus Sp. YXf3

Zhi Kai Guo, Tong Yan, Ye Guo, Yong Chun Song, Rui Hua Jiao, Ren Xiang Tan, Hui Ming Ge

J Nat Prod. 2012 Jan 27;75(1):15-21.

PMID: 22196792

Abstract:

Six new p-terphenyl derivatives, named 4″-deoxy-3-hydroxyterphenyllin (1), 4″-deoxy-5'-desmethyl-terphenyllin (2), 5'-desmethylterphenyllin (3), 4″-deoxycandidusin A (4), 4,5-dimethoxycandidusin A (5), and terphenolide (6), four new diterpenoids with norcleistanthane (aspergiloid A (12) and aspergiloid B (13)), cleistanthane (aspergiloid C (14)), and isopimarane (aspergiloid D (15)) type skeletons, and five known p-terphenyl compounds (7-11) were isolated from the fermentation broth of the plant endophytic fungus Aspergillus sp. Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison of their NMR data with those reported in the literature. Compounds 4, 6, 7, and 9 displayed moderate neuraminidase inhibitory activity with IC(50) values ranging from 4.34 to 9.17 μM.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP92944	p-Terphenyl		92-94-4	Price

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