0

Palladium-catalyzed Acetylation of Arenes

Stephen D Ramgren, Neil K Garg

Org Lett. 2014 Feb 7;16(3):824-7.

PMID: 24405108

Abstract:

A simple method for the preparation of aryl methyl ketones is reported. The transformation involves the Pd-catalyzed coupling of an acyl anion equivalent, acetyltrimethylsilane, with aryl bromides to afford the corresponding acetylated arenes in synthetically useful yields. The methodology is tolerant of heterocycles and provides a new method for arene functionalization.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP13411488 Acetyltrimethylsilane Acetyltrimethylsilane 13411-48-8 Price
qrcode