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Palladium-Catalyzed Cascade Cyclization/Alkynylation Reactions

Jianxiao Li, Shaorong Yang, Wanqing Wu, Huanfeng Jiang

Chem Asian J. 2019 Dec 2;14(23):4114-4128.

PMID: 31637860

Abstract:

Palladium-catalyzed cascade cyclization reactions have witnessed significant improvements in recent years. Among them, palladium-catalyzed cascade cyclization/alkynylation are especially attractive, which can assemble structurally diverse monocyclic, bicyclic, fused polycyclic, and spirocyclic skeletons with excellent chemoselectivities. In this Minireview, palladium-catalyzed cascade cyclization/alkynylation have been summarized and discussed in detail with focus on oxypalladation and aminopalladation-initiated cascade cyclization, intramolecular Heck-type cascade cyclization, carbocyclizations, cascade cyclizations, and other types of cascade cyclization reactions. Some significant and representative synthetic methodologies and their synthetic applications and reaction mechanisms have also been described.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP7440053 Palladium Palladium 7440-05-3 Price
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