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Palladium-catalyzed Primary Amine-Directed Regioselective Mono- And Di-Alkynylation of biaryl-2-amines

Guangbin Jiang, Weigao Hu, Jianxiao Li, Chuanle Zhu, Wanqing Wu, Huanfeng Jiang

Chem Commun (Camb). 2018 Feb 13;54(14):1746-1749.

PMID: 29379914

Abstract:

The first example of the palladium-catalyzed primary amine-directed C(sp2)-H alkynylation of biaryl-2-amines has been developed by using (bromoethynyl)triisopropylsilane as an alkynylating reagent. This protocol exhibits a broad substrate scope, excellent regioselectivity and gram-scale synthesis. Significantly, the versatility of this straightforward method was further demonstrated by controlled mono- and di-alkynylation.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP17877235 Triisopropylsilanol Triisopropylsilanol 17877-23-5 Price
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