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Palladium-catalyzed Silylation of Aryl Bromides Leading to Functionalized Aryldimethylsilanols

Scott E Denmark, Jeffrey M Kallemeyn

Org Lett. 2003 Sep 18;5(19):3483-6.

PMID: 12967305

Abstract:

[reaction: see text] A mild and general palladium-catalyzed insertion of 1,2-diethoxy-1,1,2,2-tetramethyldisilane into a variety of aryl bromides affords the aryldimethylsilyl ethers in high yields. Hydrolysis of the ethers under pH-optimized conditions results in the exclusive formation of the desired aryldimethylsilanols.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP18419846 1,2-Diethoxy-1,1,2,2-tetramethyldisilane 1,2-Diethoxy-1,1,2,2-tetramethyldisilane 18419-84-6 Price
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