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Palladium-Catalyzed sp 2-sp 3 Coupling of Chloromethylarenes with Allyltrimethoxysilane: Synthesis of Allyl Arenes

Sheng Zhang, Jinfang Cai, Yoshinori Yamamoto, Ming Bao

J Org Chem. 2017 Jun 2;82(11):5974-5980.

PMID: 28482662

Abstract:

Palladium-catalyzed remote sp2-sp3 coupling reaction of chloromethylarenes with allyltrimethoxysilane is described in this work. The allylation reaction regioselectively occurred on the para-positions of 1-(chloromethyl)naphthalenes and benzyl chlorides to form new C(sp2)-C(sp3) bonds. The reaction proceeds smoothly under mild conditions to produce allyl arenes in moderate to excellent yields.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP2551839 Allyltrimethoxysilane Allyltrimethoxysilane 2551-83-9 Price
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