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Palladium Catalyzed Vinyltrifluoromethylation of Aryl Halides Through Decarboxylative Cross-Coupling With 2-(trifluoromethyl)acrylic Acid

Subban Kathiravan, Ian A Nicholls

Org Lett. 2015 Apr 17;17(8):1874-7.

PMID: 25826014

Abstract:

An efficient Pd-catalyzed stereoselective vinyltrifluoromethylation of aryl halides, through decarboxylative cross-coupling with 2-(trifluoromethyl)acrylic acid is described. The ready availability of the starting materials, the high level of functional group tolerance, and excellent E/Z selectivity make this protocol a safe and operationally convenient strategy for efficient synthesis of vinyltrifluoromethyl derivatives.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP381986 2-(Trifluoromethyl)acrylic acid 2-(Trifluoromethyl)acrylic acid 381-98-6 Price
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