Home
Resources
Publications
Palonosetron Hydrochloride for the Prevention of Chemotherapy-Induced Nausea and Vomiting

Palonosetron Hydrochloride for the Prevention of Chemotherapy-Induced Nausea and Vomiting

Christina Ruhlmann, Jørn Herrstedt

Expert Rev Anticancer Ther. 2010 Feb;10(2):137-48.

PMID: 20131990

Abstract:

A large number of different 5-hydroxytryptamine (HT)(3) receptor antagonists have been marketed with the indication of preventing nausea and vomiting induced by chemotherapy--palonosetron is the most recently developed of these. Pharmacologic studies have revealed that palonosetron has a long half-life, a high affinity for 5-HT(3) receptors, exhibits allosteric binding to 5-HT(3) receptors and possess positive cooperativity. Although interesting, pharmacologic differences are only useful if they result in clinical advantages, such as an increase in efficacy and/or an improvement in tolerability. We summarize preclinical and clinical studies of palonosetron and compare the efficacy and tolerability with the other 5-HT(3) receptor antagonists, ondansetron, granisetron and dolasetron.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP135729623	Palonosetron hydrochloride		135729-62-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: