Home
Resources
Publications
Pancreatic Human Islets and Insulin-Producing Cells Derived From Embryonic Stem Cells Are Rapidly Identified by a Newly Developed Dithizone

Pancreatic Human Islets and Insulin-Producing Cells Derived From Embryonic Stem Cells Are Rapidly Identified by a Newly Developed Dithizone

Bashar Khiatah, Meirigeng Qi, Youjun Wu, Kuan-Tsen Chen, Rachel Perez, Luis Valiente, Keiko Omori, Jeffrey S Isenberg, Fouad Kandeel, Jiing-Kuan Yee, Ismail H Al-Abdullah

Sci Rep. 2019 Jun 26;9(1):9295.

PMID: 31243300

Abstract:

We developed an optimized Dipheylthiocarbazone or Dithizone (DTZ) with improved physical and chemical properties to characterize human islets and insulin-producing cells differentiated from embryonic stem cells. Application of the newly formulated iDTZ (i stands for islet) over a range of temperatures, time intervals and cell and tissue types found it to be robust for identifying these cells. Through high transition zinc binding, the iDTZ compound concentrated in insulin-producing cells and proved effective at delineating zinc levels in vitro.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP60106	Dithizone		60-10-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: