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Paraoxon and Parathion Hydrolysis by Aqueous Molybdenocene Dichloride (Cp2MoCl2): First Reported Pesticide Hydrolysis by an Organometallic Complex

Paraoxon and Parathion Hydrolysis by Aqueous Molybdenocene Dichloride (Cp2MoCl2): First Reported Pesticide Hydrolysis by an Organometallic Complex

L Y Kuo, N M Perera

Inorg Chem. 2000 May 15;39(10):2103-6.

PMID: 12526519

Abstract:

We report the first case of an organometallic complex that effectively hydrolyzes the organophosphate pesticides parathion and paraoxon. The complex is the water-soluble compound bis(eta 5-cyclopentadienyl)molybdenum(IV) dichloride (1), which hydrolyzes parathion to produce ethanol and deethyl parathion in a biphasic reaction in D2O. Rate accelerations were 130 and 10(5) at pH 7 and 3, respectively. Paraoxon is readily hydrolyzed by 1 to yield p-nitrophenol and diethyl phosphate with rate accelerations of 2300 and 27 at pH 7 and 3, respectively. Kinetic data for paraoxon hydrolysis by 1 are consistent with a process that involves intermolecular (delta S++ = -49 +/- 10 eu) hydroxide attack on the phosphate triester in which the aquated 1 serves as a coordinated Lewis acid that activates the organophosphate. Interestingly parathion hydrolysis by 1 occurs via nucleophilic attack at the alpha-carbon of the phosphorothioate pesticide that involves C-O bond cleavage. These parathion results represent one of the few cases of this type of unusual hydrolytic chemistry and the first case of an organometallic complex that accelerates organophosphate pesticide hydrolysis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP12184224	Bis(cyclopentadienyl)molybdenum(IV) dichloride		12184-22-4	Price

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