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PARP10 Suppresses Tumor Metastasis Through Regulation of Aurora A Activity

PARP10 Suppresses Tumor Metastasis Through Regulation of Aurora A Activity

Yahui Zhao, Xiaoding Hu, Li Wei, Dan Song, Juanjuan Wang, Lifang You, Hexige Saiyin, Zhaojie Li, Wenbo Yu, Long Yu, Jin Ding, Jiaxue Wu

Oncogene. 2018 May;37(22):2921-2935.

PMID: 29515234

Abstract:

ADP-ribosylation, including poly-ADP-ribosylation (PARylation) and mono-ADP-ribosylation (MARylation), is a multifunctional post-translational modification catalyzed by intracellular ADP-ribosyltransferases (ARTDs or PARPs). Although PARylation has been investigated most thoroughly, the function of MARylation is currently largely undefined. Here, we provide evidences that deficiency of PARP10, a mono-ADP-ribosyltransferase, markedly increased the migration and invasion of tumor cells through regulation of epithelial-mesenchymal transition (EMT), and PARP10 inhibited tumor metastasis in vivo, which was dependent on its enzyme activity. Mechanistically, we found that PARP10 interacted with and mono-ADP-ribosylated Aurora A, and inhibited its kinase activity, thereby regulating its downstream signaling. Moreover, the expression level of PARP10 was downregulated in intrahepatic metastatic hepatocellular carcinoma (HCC) compared with its corresponding primary HCC and adjacent non-tumorous tissues. Taken together, our results indicated that PARP10 has an important role in tumor metastasis suppression via negatively regulation of Aurora A activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4246445	PARP10 active human			Price

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